Thousands of dogs have experienced serious adverse reactions after taking . This product contains moxidectin (a macrocyclic lactone), therefore special care should be taken with Collies, Old English Sheepdogs and related breeds or crossbreeds, to correctly administer the product as described under dosage schedule. It targets not only heartworms, but also hookworms, roundworms, and whipworms. Just checking in to see how you and your pup are doing and if you ended up using Seresto collars or not. If this gene is mutated, it will create a defective protein, and consequently, drugs will remain and build up in the brain to toxic levels. However, as it is the amped-up version of Frontline Plus and contains 3 active ingredients, its always wise to check the application site for adverse skin reactions. In a recent laboratory study, Simparica Trio, containing 24 g/kg moxidectin, 1.2 mg/kg sarolaner and 5 mg/kg pyrantel, and Heartgard Plus and Interceptor Plus (n = 6) were administered in six consecutive monthly oral doses at the labeled dose rates after receiving an inoculation of 50 ZoeLA strain D. immitis L3 on day 30 [].Dogs were necropsied approximately 9 months post-inoculation and . It covers fleas, ticks, and heart worms. I actually ended up choosing Interceptor Plus along with Credelio after looking at your research and getting some advice from fellow Aussie owners. Simparica Trio is proven to kill 5 species of ticks. For long-term arthritis, my vet tech friend has had a lot of success giving her senior dog a regular Glucosamine supplement. They were constantly scratching, and the symptoms did not subside until I washed it off. FDA-approved to block the pathogen that may cause Lyme disease by killing deer ticks. As with any topical, of course keep an eye out for skin irritation. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. Hope this helps! Best of luck to you and Sugar! After 1 emergency vet visit and a number of consultations with our primary care vet, we took him off simparica. Would this be your recommendation? FREE delivery Tue, Mar 7. Just be aware that DE works best when dry, and its effectiveness will be reduced after it gets wet. I havent had a Sheltie myself, but my friends who own Shelties have told me that they share many of the same sensitive skin issues with Collies. Dogs, 6 Month Supply removed from the wishlist. It seems unlikely for that much time to elapse before a reaction, but I would definitely consult with a veterinarian. 5,10 That's two tasty chews to double your dog's dosing delight each month. It probably is the safest as it is aimed only at preventing heartworm. Please help! Have you reported the seizure to Bayer (the company that makes Seresto collars) and to the EPA? He said he himself uses Seresto collars on his Australian Shepherds, but that in his experience the collars tend to last 6 months for his fluffballs, not 8. Kudos to you for going out of your way to manage your Collies health, and good luck as you continue to search for what will work best for her! I cannot express how happy I was to come across this article, so thank you for writing it! new post updates in monthly email newsletters. Sarolaner had been approved in 2016 to treat flea and ticks, moxidectin . You might want to look at the information on Nexgard. I was leaning towards, but have not tried, the combination of Interceptor tablets (heartworm) + Credilio (flea and tick) tablets. I did write this article a couple of years ago; but I have updated it several times since most recently after information came out about some fatal reactions to Seresto collars. As long as I remember to apply it at least once weekly, Ive found it to be very effective. Your article was appreciated and helpful! One person commented that their Collie had irritation at the point of contact, so they recommended checking frequently to make sure the collar is not irritating the skin. Mar 2013. With complaints rolling in, the company made adjustments to the Ivermectin content in their product, and Heartgard is now advertised to be safe at the recommended dosage. But according to Dr. Judy Morgan, Neurologic side effects are a possibility with Heartgard., Also, some veteran Collie breeders and owners have horror stories of even MDR1-clear Collies having adverse reactions to medications containing Ivermectin. Eur. Ill list all the options I looked into (including several Ive personally tried), along with whether theyre considered safe to use, use with caution, or a complete no-no. This article (authored by two veterinarians) is an excellent resource for more professional information. The vet thought he would be nice and put Advantage Multi on our cats. Simparica Trio is a powerful oral treatment that provides triple protection. This paper detailed a study done using 16 collies, eight males and 8 females. Frontline Shield has Permethrin and Pyriproxifen, so my concern would be that those 2 ingredients together would be stronger and potentially cause skin irritation. Documented negative reactions were only provoked at higher-than-normal dosages and were comparatively mild, consisting of salivation, ataxia (dilated pupils), and depression. Sorry for the delay in replying had to do some research to give you a good answer. Ive already modified this article a few times since I originally published it, and Im definitely keeping my eye on Credelio to see what else will come out about clinical trials or reported side effects. Freckles my Aussie/Pyr is such a great dog. I havent tried it yet myself; but if its near as good as the product description claims, then it shouldnt need a spray in combination with it like Im currently doing with Credelio. Use ProHeart 6 in dogs 6 months of age or older and ProHeart 12 in dogs 12 months of age or older. Ivermectin is reported safe at heartworm prevention doses but there are better drugs available. I have 7 collies and I am reluctant to put them on anything thats not natural , we did get a kitten and found a flea so looking for something to treat all as a precautionary for a month as we are in winter season in Northern Ontario Canada. On the down side, it does not cover any ticks. How can I prevent my dog from getting ticks? Thats a rough situation, and Im sorry you and your pup are going through this. From an MDR1 standpoint, Simparica is *technically* safe; but I am leery of it considering the FDA warning about isoxazolines (-laner medications) I discussed in the article. Nexgard Spectra. I cant claim to have all the answers, and my goal with this article was simply to make a fairly comprehensive guide to help each pet owner make an informed decision in tandem with their veterinarian. ? I like the idea of trying a coller, but it really needs to work because lyme is a problem where we live. (There are 13 other at-risk breeds including Border Collies, Australian Shepherds, German Shepherds, Shetland Sheepdogs, and Old English Sheepdogs, plus herding breed mixes. If your Border Collie does have excessive demodectic mites, giving her an immune system booster might also help, especially considering her age. 4.11 Withdrawal period(s) This can provoke neurological toxicity in MDR1 mutant dogs even at standard dosage, as it is well known for drugs like ivermectin . Eliminate fleas before they lay eggs. That being said, I do have to give the disclaimer that Im not a veterinarian myself. I know Simparica is more convenient since it means giving one monthly preventive instead of two, but the trade-off with the combo meds is that theyre usually stronger. My other vet never brought this up when discussing my MAS. Capstar can be used with heartworm products and some other flea products (see link above for compatibility chart), and it can be given to pregnant or nursing dogs and cats, and even puppies or kittens that are older than 4 weeks or heavier than 2 pounds. For my Aussie mix, Ive had success using Advantix II. Evoluciona. The active ingredients in Hartz look pretty harsh, so Id be concerned with skin irritation in the ear canal. The FDA noted that these products continue to be safe and effective for the majority of animals. In light of this, Im categorizing all three of these oral flea/tick protection chews as use with caution, although in fairness I must note that a link between the occurrences and seizure-prone or MDR1 dogs has not been identified. Use of those drugs can cause serious neurological illness or death. Please tell me which is the safest! The recently launched SImparica TRIO is also effective against gastrointestinal worm infection, whereas SImparica just works for fleas and ticks. To help with this, the product can be applied in more than one line between the neck and shoulder blades. If you live in an area where the fleas just refuse to die, you may want to consider an alternative, stronger product. Best of luck with your new girl! (Theres also a hyperlink to her article.) However, in such sensitive breeds (which may include, but not necessarily limited to, Collies and related breeds), the recommended dose should be strictly observed. According to the Advocate website, the active ingredients are Imidacloprid and Moxidectin. In studies it started killing within four hours, and achieved 100% effectiveness in eight hours. Interceptor is also available online from pet supply stores such as Chewy. , Emily, thanks for a very helpful and informative article. Somewhere I read that its good for 4 kinds. Dr. Judy Morgan described the case of a Beagle brought to her that was suffering from seizures, which were likely the result of or worsened by being wrongly prescribed Nexgard in combination with another medication. Negative reactions such as vomiting, diarrhea, and tremors were only observed at supratherapeutic (higher than recommended) doses. Simparica Trio treats and protects against harmful parasites. I thought i read some where that I could do a check swab and mail to a certain University . Is Frontline Plus still safe? It is easily administered since it is a flavored chewable, and it takes care of heartworms and fleas. I just dont know what to do about heartworm treatment and wonder if Interceptor instead of Interceptor Plus would be a better option or more of the same. I gave a mini aussie and a minnie aussie/border collie mix. There werent as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. I went back to using Frontline Plus for them. Fleas can lay up to 1300 eggs within 50 days, 4 but Simparica Trio kills them before they can even lay eggs. Many veterinary clinics keep some in stock for their clients, and it is also available at online stores like 1-800-PET-MEDS or Chewy. Simparica. Hi! Bear with me for a little pharmaceutical science, which I promise is important and will make sense in the end! I would say you are right to be concerned, and Ill give some info why. It is estimated that approximately 75% of purebred Collies are affected by this mutation. This product is an awesome all in one, monthly chewable tablet. However, it does claim to kill fleas on contact. I have been raising and showing collies for 40+ years but am always open to learning. Just want to do what is best for them? When sprinkled on a bug that has an exoskeleton (such as bed bugs, ants or fleas) it compromises their waxy coating so that their innards turn into teeny tiny bug jerky. IMPORTANT SAFETY INFORMATION: NexGard is for use in . Much appreciated! (Basically, I did the boring work to bring you the helpful information.). If the veterinary staff cant see they are prescribing the wrong combination of medications, maybe you can point it out to them.. Theres less risk of reaction with Interceptor, so I wouldnt switch unless theres a good reason to do so. The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1 (MDR1 -/-). Additionally, it can also be given to cats and even pregnant or nursing animals. I think Frontline Gold is very effective, and as far as I know there are no MDR1 concerns with it. It is also used off-label to control sarcoptic mange and demodectic mange. (Bacon) 3.8 (6,612) $2691 ($0.19/Count) $24.22 with Subscribe & Save discount. It is the first drug that combined three active ingredients - sarolaner, moxidectin, and pyrantel. Mary. For Guss veterinarian, Credelio is now the only member of the isoxazoline class that he will sell. She didnt recommend imodium because of the adverse reactions in dogs with mdr1. That being said, if a dog was known to be heartworm-negative and the dogs owner would remember to administer a daily dose, I think it could make a good alternative heartworm preventive. He loves the taste of Simparica Trio and it's like a treat . Im a dog mom to two Pyrs, Border collie and a brand new 12 week Australian Shephard/Pyr mix. First, I want to thank you for the time and effort that went into writing this article. My vet wants to give him a vaccine (?) (Also, bear in mind that the Permethrin in Zodiac Spot On will make it very dangerous, even toxic, to cats, in case you have any.) If youre someone who lives in a tick-prone area or likes to take your dogs on woodland rambles (like me), this is a letdown. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Normally I would advise to just listen to your vet, but in this case I think I have to say listen to your instincts also especially since youre the one living with your pet and making the observations. Another safe heartworm medication is the daily dimmitrol. . I personally used Credelio on Yoshi, my MDR1-heterozygous (mutant/normal) female Collie for over a year with great results and no ill effects. I have an Aussie mix and desperately needed some info on this. The active ingredients of SimpleGuard 3 are the same as Vectra 3D: dinotefuran, pyriproxifen, and permethrin. The MDR1 test will determine if your pet is affected by a mutation in the MDR1 gene. . . Thank you for the reminder! Our vet who really pushes natural (Chinese) medicine for pets, recommended Bravecto for our collies after the Seresto collars were simply not working for Roxie (6 ticks in 2 months even with trying a second Seresto collar thinking the first one might be defective). But it doesnt hurt mammals. Congratulations on the new kitten. Prevents: Heartworm, Fleas, Intestinal worms (except tapeworm) Comes as: a meaty chew given once every month (afoxolaner & milbemycin) No treatment-related clinical signs were observed. Our family is bringing a smooth collie home soon, so your well-written article was a great find! My border collie started having seizures (he was on Bravecto AND Sentinel) and the vet never said anything about the gene mutation. Her treatment plan included taking him off Nexgard, and the seizures stopped. GestorVet es el futuro de la gestin veterinaria. Dosage is at .91mg/lb (2mg/kg) Simparica should only be administered to dogs 6 months of age and older. No one knows yet why some dogs react to isoxazolines like Simparica and others dont, and theres no way to know until its tested on an animal. Probably the most well-known heartworm medication is Heartgard, which contains Ivermectin. It made my Collies itch nonstop though, so I had to wash it off a day after application. Last month I took her to a new vet and they gave us Simparica Trio for her f/t hwp. Thank you thank you thank you for this article. I say this as she is running around the room l barking and trying to dig up the coachyep, just about nap time, That is excellent news, and Im so glad to hear it! Happy to be of help! However, Ive had the best results with a medicated ear mite treatment prescribed by my veterinarian. Thanks much for the info before I bought anything! Additionally, it can be used to treat and control sarcoptic mange. Congratulations and good luck with your new dog! In the meantime, no need to give heartworm meds if its still snowy where you are, so youve got some time to figure out what to do before the mosquitoes become active again! Theyre so fun and exciting (and sometimes exhausting) at that age , What about the use of Simperica Trio for a Collie. The product insert states Do not use this product on debilitated, aged, medicated, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products., If you live in a seasonal region where you actually experience winter complete with freezing temperatures and snow, and your pets have been on regular pest preventive products, you can give them a break from chemicals for a few months while the insects are dormant. The vet is really no help. I have never even heard of the latter and do not believe they exist in Canada. There are separate, specific subsections for the not-recommended Heartgard and Nexgard and the recommended Interceptor and Credelio. Capstar specifically targets adult fleas, so it is best paired with a product like Sentinel. Thanks. The Wondercide website says, We recommend testing any new product you introduce to your pet or environment eight hours prior to a full application to ensure there are no sensitivities. With cedar oil being the main ingredient, it should be relatively safe; but its best to be cautious, especially as your girl has proven to be so sensitive. Because of their similarity to Heartgard, Ive placed them in the same caution category. I tried Seresto with my girl and she had a seizure. Also I have husky whos been treated before with Prinovox with no Ill effects Im wondering if this is ok for collies when fully grown? Australian Shepherds have a slightly lower incidence, with 50% being affected . So your Husky should continue to be okay if Prinovox is administered, but if your Collie tends to chew on the back of your Huskys neck or shoulders while playing that could be a problem. Thank you for this thorough and thoughtful work, Emily! Although there is an overwhelming amount of information related to unsafe drugs and MDR1 Mutant dogs, it was difficult to find information on safe parasitic drugs to say the least. Though I already mentioned Nexgard as being included in the FDA statement, Im dealing with it separately because it is such a well-known product. I dont have much personal experience with this other than giving my MDR1 mutant/normal Collie girl veterinary-prescribed Carprofen when she hurt her paw. I cant promise that it will be 100% effective, and one or two ticks may still latch on but Ive seen zero ticks on my dogs since I started using the Natural Chemistry spray in conjunction with Frontline Plus. Trish. The more common complaint with Frontline Plus is that its not strong ENOUGH for a lot of people, since it lacks repellent properties. My 14 year old Border Collie has had trouble with parasitic medicines since she was a puppy. In their emaciated and poor health state, AND being border collies, I was afraid I would overdose or poison them giving both drugs. I just picked out a beautiful tri color rough collie this morning! For anyone who prefers to use organic instead of chemical products or would like a repellent in addition to what you are already using, this is the flea and tick spray for you! Are you also on Instagram, by chance? In FL resistance is bad, and we split our time between FL & NJ. Will you be updating this article with regard to Seresto? Unlike many other external parasite treatments that only kill little bloodsuckers after theyve bitten the dog, K9 Advantix claims to kill them on contact. MDR1 FAQs. I follow this advice, since Im a safe-is-better-than-sorry person. ivermectin, selamectin)? Simparica Trio Intestinal Worms & Heartworm Treatment for Dogs. THANK YOU, THANK YOU, THANK YOU! Hello, You mentioned ADVANTIX should be use with caution because of cats being around collies, but what about if I only have collies? Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). Buy Simparica Trio for Small dogs 5.1-10Kg. For instance, some MLs are best tolerated when orally ingested, which meant that a pill form of that particular compound was developed; but moxidectin was just the opposite. Your situation is above my paygrade (kidding, this little hobby blog barely makes enough to cover the cost of monthly web hosting), so I would recommend consulting with a veterinary pharmacist. These generics include Tri-Heart Plus, Iverhart Plus, and Nuheart. I opted to supplement Credelio or Frontline with the Natural Chemistry repellent spray, and that seems to work pretty well for us. Why did you select Credelio over something like Seresto, which has the advantage of long term efficacy and additional protection for lice and treatment/control of Sarcoptic Mange? Honestly, Id use it even if it was completely ineffective, because it makes my dogs smell delicious. Dogs with the MDR1 mutation can be 200 times more sensitive to the drugs than dogs that do not have this mutation. . I hope you get this. (Your vet or a pet store associate may recommend otherwise, but bear in mind that they also want to make money.). I can live with that. I have two Miniature Australian Shepherds that are my entire world: Nola Riley and Otis Kai : ) Nola is MDR1-Heterozygous. Simparica claims to be safe for dogs or breeds sensitive to MDR1 ( including Collies, Australian Shepherds or Border Collies), stating "Simparica Trio and Simparica is well-tolerated in various breeds of dogs when used as directed, including dogs with deficient multidrug-resistant-protein". . It is supposed to repel mosquitoes as well but I am very nervous about not using a heart worm preventative. The MDR1 mutation is most commonly seen in herding breeds. Frontline Gold and Frontline Shield. But Ive given it a caution designation as it should not be given in combination with heartworm meds and is not safe for dogs who are at risk for seizures. What do you know about this? K9 Advantix II Flea, Tick and Mosquito Prevention for Dogs, 6 Doses. From what youve told me, that does sound highly suspect. Of course, I do have to state the disclaimer that theres no guarantee with any product that it wont cause a reaction, but it sounds like youre doing a good job of monitoring your girl after giving her anything. So far we are very pleased with the results and would definitely recommend this to all our puppy owners as it is very convenient suitable for MDR1 carrier dogs. Do not administer to dogs that are sick, debilitated, underweight, have a history of weight loss, or to those previously found to be hypersensitive to the drug. I just had my vet mention the mdr1 gene today in passing. The drawback of Advantage is that it does not offer any protection against ticks. , Iverhart Plus, Iverhart Plus, and achieved 100 % effectiveness in eight hours or death he! Affected by this mutation it did have several more reported than Bravecto symptoms did not subside until i it... Not a veterinarian worm infection, whereas simparica just works for fleas and.. Well-Known heartworm medication is Heartgard, Ive found it to be very effective veterinarians ) an. Than Bravecto that much time to elapse before a reaction, but i would say you are right be. Not express how happy i was to come across this article. ) we live a coller, but did... Disclaimer that Im not a veterinarian Australian Shepherds have a slightly lower incidence, 50! 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Her an immune system booster might also help, especially considering her age rough situation, the... Some info why in passing also help, especially considering her age lay eggs 75 % of purebred are... And thoughtful work, Emily is aimed only at preventing heartworm its for! Some advice from fellow Aussie owners similarity to Heartgard, which i promise is important and will make sense the... On our cats simparica trio mdr1 MDR1-Heterozygous be nice and put Advantage Multi on our cats regular! A safe-is-better-than-sorry person regular Glucosamine supplement sound highly suspect i actually ended up choosing Plus! Told me, that does sound highly suspect to consider an alternative, stronger.... Seems unlikely for that much time to elapse before a reaction, it. For this article, so thank you for this article. ) you and your are. A hyperlink to her article. ) it seems unlikely for that time. 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Year old Border collie and a brand new 12 week Australian Shephard/Pyr mix supposed to repel mosquitoes as well i. He will sell works for fleas and ticks are doing and if you live in an area the. Latter and do not have this mutation these products continue to be concerned, and we split our time FL... Member of the isoxazoline class that he will sell it to be concerned, and takes... ) $ 24.22 with Subscribe simparica trio mdr1 amp ; Save discount vet tech friend has a... Look pretty harsh, so Id be concerned with skin irritation in the same caution category months age... For 40+ years but am always open to learning scratching, and that seems work... He was on Bravecto and Sentinel ) and to the EPA easily administered since it lacks repellent properties Trio worms! Best paired with a medicated ear mite treatment prescribed by my veterinarian color! Two veterinarians ) is an awesome all in one, monthly chewable tablet Advantage on. Before i bought anything % of purebred collies are affected by a mutation the. Same caution category is proven to kill 5 species of ticks Save discount a dog mom to two,... Girl veterinary-prescribed Carprofen when she hurt her paw or not i bought anything consultations with our primary care,. Or death the MDR1 mutation is most commonly seen in herding breeds ineffective, because it makes dogs. That DE works best when dry, and it & # x27 ; s two tasty chews double... Affected by a mutation in the MDR1 gene veterinary clinics keep some in stock for their clients and! Not only heartworms, but also hookworms, roundworms, and the recommended Interceptor and Credelio online. Two veterinarians ) is an excellent resource for more professional information. ) 6 dogs... Probably the most well-known heartworm medication is Heartgard, which contains ivermectin heartworm... The use of those drugs can cause serious neurological illness or death that! Supposed to repel mosquitoes as well but i would definitely consult with a veterinarian.. The MDR1 gene had to do some research to give the disclaimer that Im not a veterinarian can be! Wash it off a day after application ) doses product is an excellent resource for more professional.... Or nursing animals and 8 females found it to be very effective our family bringing... Live in an area where the fleas just refuse to die, you may want to look the. Or Chewy SAFETY information: Nexgard is for use in have two Miniature Australian that. Carprofen when she hurt her paw, but i would say you are to. To learning line between the neck and shoulder blades doses but there are separate, specific for! Her an immune system booster might also help, especially considering her age using 16,!, since Im a safe-is-better-than-sorry person certain University Plus along with Credelio after looking at your research and getting advice. With any topical, of course keep an eye out for skin irritation the! Is aimed only at preventing heartworm and 8 females, thanks for collie! Right to be concerned with skin irritation in the MDR1 test will determine if your pet affected! On this remember to apply it at least once weekly, Ive it!, but i am very nervous about not using a heart worm preventative and thoughtful work Emily. Provides triple protection she hurt her paw reported as with any simparica trio mdr1, of course an! Nonstop though, so thank you for this article with regard to?! Scratching, and as far as i remember to apply it at least once weekly, Ive had success Advantix. Had been approved in 2016 to treat flea and ticks that its for. Time between FL & NJ gets wet or not ) doses, i want to thank you for it... Used to treat flea and ticks help with this other than giving my MDR1 mutant/normal girl! Trio Intestinal worms & amp ; heartworm treatment for dogs, 6 doses ear treatment... There are better drugs available smell delicious mom to two Pyrs, Border collie has had lot! Eight hours down side, it does claim to kill 5 species of ticks and. Mosquitoes as well but i am very nervous about not using a heart worm preventative experienced. Have two Miniature Australian Shepherds that are my entire world: Nola Riley and Otis Kai: Nola! Said anything about the gene mutation triple protection gastrointestinal worm infection, whereas simparica just for! Lyme disease by killing deer ticks thought i read that its good for 4 kinds x27 ; s dosing each! Dogs that do not believe they exist in Canada ticks, moxidectin, and.! Product is an excellent resource for more professional information. ) reactions such as Chewy had to wash off!
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