Furthermore, use during the last trimester of pregnancy can induce significant neonatal nephrotoxicity. WebFamotidine renal clearance exceeded inulin clearance by an average of 152%, indicating that renal tubular secretion of famotidine occurred. Symptoms of an overdose of this drug can include: If you think youve taken too much of this drug, call your doctor or local poison control center. Merck & Co., Inc (2002): 2. This irritation could make your symptoms worse. To find out how this drug might interact with something else youre taking, talk to your doctor or pharmacist. Learn more about the food you should eat for prevention or symptom management. The kidneys of older adults may not work as well as they used to. Applies to famotidine: compounding powder, intravenous solution, oral powder for reconstitution, oral tablet, oral tablet chewable, oral tablet disintegrating. Nonsteroidal anti-inflammatory drugs and prostatic diseases. The main job of the prostate is to contribute fluid to semen. They may also ask you to avoid beverages with caffeine. When a man gets older, for reasons that still arent completely understood, the prostate begins to grow. Other sleep aids often contain the antihistamine doxylamine (eg, Unisom).. Toxicity A patients complete blood count (CBC), gastric pH and occult blood in patients with gastrointestinal (GI) bleeding should be monitored. These changes would be expected to cause fluid retention, edema, and elevated serum creatinine. 8600 Rockville Pike The patch is not to be used if the patient has kidney stones. 2006;71(247):77314-77353. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Check with your doctor immediately if any of the following side effects occur: Rare Anxiety bleeding gums blistering, peeling, or loosening of the skin blood in the urine or stools bloody, black, or tarry stools cough difficulty breathing discouragement fast, irregular, pounding, or racing heartbeat or pulse feeling sad or empty irritability Famotidine is used to relieve symptoms of acid reflux and heartburn. People with moderate or severe kidney disease: Your doctor may decrease your dose of this drug by half. Dont put this medication in your cars glove compartment or leave it in the car. The increased levels may cause more side effects, such as confusion and an irregular heart rhythm called QT prolongation. All rights reserved. These antihistamines have low receptor specificity and interact with both peripheral and central histamine receptors and readily cross the blood-brain barrier. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Ahmed MH. Enlarged prostate. All of these medicines can worsen BPH symptoms. What Are Side Effects of Pepcid? Your doctor may start you on a lowered dose or a different dosing schedule. To help avoid interactions, your doctor should manage all of your medications carefully. Case Rep Nephrol. (2011, October), Pepcid famotidine tablet, film coated. Pepcid AC (famotidine)." Talk to your doctor about other drug options that may work for you. The phase IV clinical study analyzes which people take Pepcid and have Urinary retention. In men, a blockage can be caused when the prostate gland gets so big that it presses on the urethra. Dont worry about airport x-ray machines. Call your doctor right away if you have serious side effects. Symptoms can include: sexual problems, such as decreased sex drive, yellowing of your skin or the whites of your eyes. Cialis and generic tadalafil are available from online services, along with other options for people looking to buy ED medication online. Certain histamine2 (H2)-blockers carry the kidney disease precaution, as they are primarily eliminated renally.7 These include Pepcid AC Maximum Strength and Zantac 150.5 The lower-dose formulations of both of these products are not required to carry a kidney disease precaution. By Mark D. Coggins, PharmD, CGP, FASCP Never try to catch up by taking two doses at once. urinary retention, when one is unable to urinate Prescription medications and BPH If you take one of these drugs, check with your doctor. Drug information provided by: IBM Micromedex. These include: Avoiding or reducing intake of certain foods, such as dairy and meat, may also help your prostate health improve. They can cause incontinence and urinary retention. They may be stored for a short time from 59F to 86F (15C to 30C). Patients more prone to this adverse effect include those with volume depletion, underlying kidney disease, congestive heart failure, liver dysfunction with ascites, and the elderly. www.nlm.nih.gov/medlineplus/ency/article/000381.htm. Famotidine is substantially excreted by the kidney; thus, it may be useful for healthcare professionals to monitor renal function especially in elderly patients. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. 2013;2013:124604. www.ncbi.nlm.nih.gov/pmc/articles/PMC3914170/. Famotidine works by blocking the histamine 2 (H2) receptor in your stomach. Heart rate and rhythm problems. These drugs, which are called vasopressor adrenergics, worsen BPH symptoms because they tighten muscles in the prostate and bladder neck. Ann Pharmacother. Last updated on Jan 11, 2023. Prescription famotidine oral tablet is available as a generic drug and as a brand-name drug. An interaction is when a substance changes the way a drug works. As men age, a large percentage of them develop a condition known as benign prostatic hyperplasia, or enlargement of the prostate. BioMed Research International. * Approximation only. Famotidine can cause a severe allergic reaction. Nonsteroidal anti-inflammatory drugs (NSAIDs) are popular pain relievers that have a conflicting relationship with BPH symptoms. You may need to show airport staff the pharmacy label for your medication. Check with your doctor immediately if any of the following side effects occur while taking famotidine: Some side effects of famotidine may occur that usually do not need medical attention. 1. Heres a guide to the medications, foods, and drinks to watch out for if you have BPH. CDC. When your bladder fills up (and is holding 3. Gastrointestinal. (2018). These sedating antihistamines often are used alone or in combination with other ingredients in cold and cough medications, and over-the-counter (OTC) sleep aid products. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. These side effects may go away during treatment as your body adjusts to the medicine. It is often used in gastroesophageal reflux disease. Neurological problems. Peeing is normally a well-orchestrated process. Pharmacists are in a unique position with regard to counseling about OTC products. Check with your doctor immediately if any of the following side effects occur while taking famotidine: Rare Anxiety bleeding gums blistering, peeling, or loosening of the skin blood in the urine or stools bloody, black, or tarry stools cough difficulty breathing discouragement fast, irregular, pounding, or racing heartbeat or pulse If you miss doses or dont take the drug on schedule: Your medication may not work as well or may stop working completely. There are two other classes of histamine receptors: H-3 and H-4. [Ref], Very rare (less than 0.01%): Chest tightness, prolonged QT interval, Frequency not reported: Arrhythmia, atrioventricular block, palpitation[Ref], Very rare (less than 0.01%): Impotence[Ref], Frequency not reported: Conjunctival injection[Ref], Frequency not reported: Gynecomastia[Ref], Pepcid, Pepcid AC, Heartburn Relief, Pepcid Oral Suspension, Pepcid AC Chewable Tablets. If you take too much: You could have dangerous levels of the drug in your body. gastroesophageal reflux disease (GERD). omeprazole, famotidine, pantoprazole, Protonix, Nexium, sucralfate, esomeprazole, Pepcid, lansoprazole, ranitidine. conditions where your stomach makes too much acid. Men with BPH need to follow the treatment plan their doctor prescribes. On the other hand, research shows some NSAIDs can worsen urinary retention. This receptor helps release acid in your stomach. These antihistamines are more selective on peripheral H1 receptors and have a lower affinity for cholinergic and alpha-adrenergic receptor sites, which reduces the risk of anticholinergic and central nervous system side effects. Symptoms can include: Severe muscle problems. It is also important to encourage patients to read product warnings and seek advice from healthcare providers before using OTC medications. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. The prostate is under the bladder and in front of the rectum. Urinary Retention and Medication Utilization on a Palliative Care Unit: A Retrospective Observational Study. Epub 2018 Jan 16. (n.d.). The use of the eHealthMe site and its content is at your own risk. Many insurance companies require a prior authorization for this drug. Accessed June 20, 2014.8. This drug hasnt been studied in children under 1 year of age for the treatment of ulcers. 2023 Healthline Media LLC. In addition to causing significant patient harm, the use of anticholinergic medications in older nursing home patients negatively impacts Centers for Medicare & Medicaid Services quality measures, such as the use of high-risk antipsychotic medications, the percentage of patients with a decline in their ability to perform activities of daily living, the percentage of patients with falls and serious injury, and urinary tract infection rates. It results in pain. Even when first-generation antihistamines are used at the lowest doses recommended by the manufacturer, they can cause serious central nervous system side effects, including dizziness, hypotension, and next-day sedation. Urinary retention and post-void residual urine in men: separating truth from tradition. For many men, benign prostatic hyperplasia (BPH) is a normal part of growing older. Cunningham GR, et al. If you are a Mayo Clinic patient, this could Famotidine is also available as an over-the-counter drug. Some nonprescription products are eliminated from your body via your urine. Because of the complex mechanism of micturition, many drugs can Keep them away from light. 2 P. 6. Figure out which ones are still safe for you to take, which ones you might need to change, and which ones might require a dosage adjustment. It does this by reducing the amount of acid in your stomach. These antihistamines also are potent muscarinic receptor antagonists that can lead to serious anticholinergic side effects, such as sinus tachycardia, dry skin, dry mucous membranes, dilated pupils, constipation, ileus, urinary retention, and agitated delirium.3 The mnemonic blind as a bat, dry as a bone, red as a beet, mad as a hatter, and hot as a hare often is used to help describe and identify patients suffering from anticholinergic syndrome (see Table 2 below). Eventually, it weakens to the point that it cant release urine normally. WebFamotidine renal clearance exceeded inulin clearance by an average of 152%, indicating that renal tubular secretion of famotidine occurred. These conditions include Zollinger-Ellison syndrome. This leads to significant central nervous system side effects, including sedation, drowsiness, somnolence, fatigue, cognitive decline, psychomotor effects, and loss of coordination. Accessed June 20, 2014. eHealthMe is studying from 66,209 Famotidine users for its effectiveness, alternative drugs and more. What Are Side Effects of Pepcid? Antihistamines, such as diphenhydramine (Benadryl), are often used to treat allergic reactions. By their 80s, the vast majority of men will have prostate growth and its associated symptoms. This obstructing pressure makes it harder for urine to leave the body and prevents the bladder from fully emptying. They include some antacids (products containing magnesium and/or potassium), other stomach medications (some products containing ranitidine or famotidine), some laxatives (those containing magnesium), and certain antihistamines (loratadine, cetirizine, and fexofenadine). Educating older patients and their caregivers is especially important because of the widespread OTC availability of these antihistamines. Pepcid is available as a generic drug. Zhang Y, Gong L, Zhang Y, Dong S, Shi J, Li X, Guo Y, He S, Wu X, Liu S, Liu H, Zhang L, Yu J. Clin Interv Aging. Ibuprofen (Advil, Motrin) and aspirin (Bayer, Ecotrin) are examples of NSAIDs. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW Mayo Clinic on High Blood Pressure - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Elderly patients are at higher risk for developing drug-induced urinary retention, because of existing co-morbidities such as benign prostatic hyperplasia and the use of other concomitant medication that could reinforce the impairing effect on micturition. Oxytrol for Women (oxybutynin transdermal system) package insert. Front Med (Lausanne). Stress incontinence. Applies to famotidine: compounding powder, intravenous solution, oral powder for reconstitution, oral tablet, oral tablet chewable, oral tablet disintegrating. All of these medicines can worsen BPH symptoms. eCollection 2022. Although not all of these side effects may occur, if they do occur they may need medical attention. J Clin Psychiatry. Older adults are especially sensitive to the central nervous system- and anticholinergic-related side effects of sedating antihistamines because of decreased cholinergic neurons or receptors in the brain, reduced hepatic and renal function, and increased blood-brain permeability. Or they may have you take one dose every 3648 hours instead of every day. urinary retention, when one is unable to urinate Prescription medications and BPH If you take one of these drugs, check with your doctor. WebUrinary retention is a condition in which impaired emptying of the bladder results in postvoidal residual urine. Healthline Media does not provide medical advice, diagnosis, or treatment. This raises your risk of side effects. Alternatives to Tamsulosin (Flomax), Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, Prevention Diet: Foods for an Enlarged Prostate, What to Drink for an Enlarged Prostate (BPH): Green Tea and More, 6 Natural Remedies for Enlarged Prostate (BPH). No significant changes in the clearances of creatinine or inulin, or the fractional clearance of creatinine were A prescription for this medication is refillable.You should not need a new prescription for this medication to be refilled. Patients with Alzheimers disease are at particular risk as caregivers may purchase these medications without understanding the associated risk of exacerbating the disease. The second-generation nonsedating antihistamines generally are considered as safer alternatives for use in older adults who require treatment for allergic rhinitis and other allergy symptoms. National Library of Medicine Tricyclic Antidepressants. 2023 Healthline Media LLC. (Acidic foods include tomatoes and citrus fruits.) Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. They can also decrease your awareness that you need to go to the bathroom. Generic drugs usually cost less. You can learn more about how we ensure our content is accurate and current by reading our. It works by decreasing the amount of acid produced by the stomach. Learn about the symptoms of BPH and how to ease them, complications from long-term BPH, and medical and surgical treatment options. 2011 Apr;107(8):1265-72. doi: 10.1111/j.1464-410X.2010.09600.x. health information, we will treat all of that information as protected health This site needs JavaScript to work properly. Serious side effects and their symptoms can include the following: Disclaimer: Our goal is to provide you with the most relevant and current information. All possible dosages and drug forms may not be included here. All of these medicines can worsen BPH symptoms. Mayo Clinic does not endorse companies or products. Effect of Transcutaneous Acupoint Electrical Stimulation on Urinary Retention and Urinary ATP in Elderly Patients After Laparoscopic Cholecystectomy: A Prospective, Randomized, Controlled Clinical Trial. generic drugs) are not considered. For the same reasons mentioned above (i.e., avoiding hypermagnesemia), the precaution is found on magnesium salicylate-containing analgesics, such as Doans Pain Reliever.5. Your doctor may suggest that you avoid spicy, acidic, and fatty foods while you take this drug. Chaudhari D, Crisostomo C, Youngberg G. Acute oxalate nephropathy associated with orlistat: a case report with a review of the literature. MedlinePlus. To comment on this article, contact [email protected]. Orlistat can induce oxalate nephropathy "Product Information. Risk of first-generation H(1)-antihistamines: a GA(2)LEN position paper. FOIA Some of these medicines are labeled with a warning about their use in men with BPH. [Ref], Common (1% to 10%): Constipation, diarrhea, Uncommon (0.1% to 1%): Nausea, vomiting, flatulence, dry mouth, abdominal discomfort or distension[Ref], Convulsions occurred in patients with renal dysfunction. Famotidine oral tablet doesnt cause drowsiness, but it can cause other side effects. Some nonprescription products can make it even harder to urinate, and the patient who takes them without reading and following the label may need to visit an emergency room to be catheterized so the bladder can be emptied. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 4 Apr 2023), ASHP (updated 12 Mar 2023) and others. www.cdc.gov/cancer/prostate/basic_info/symptoms.htm. www.nlm.nih.gov/medlineplus/ency/article/000891.htm. Accessed June 20, 2014. Animal studies do not always predict the way humans would respond. You may report side effects to the FDA at 1-800-FDA-1088. That gives rise to issues with urgency or frequency. Reproduction in whole or in part without permission is prohibited. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Over-the-counter medications (OTC) and BPH. Research in animals has not shown a risk to the fetus when the mother takes the drug. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Benign prostatic hyperplasia (BPH). Different individuals may respond to medication in different ways. The possible sequelae are life-threatening nephro-toxicity, such as acute renal failure and serious fluid and electrolyte disorders. Neither carries a warning concerning the urinary tract.5, In regard to gastric products, patients may try such antacid ingredients as calcium carbonate (e.g., Tums) or bismuth subsalicylate (e.g., Pepto-Bismol). Dont store this medication in moist or damp areas, such as bathrooms. Can I take omeprazole in the morning and famotidine at night? They may also try the lower dose versions of Pepcid and Zantac, neither of which carries a urinary tract warning. In men, a blockage can be caused when the prostate gland gets so big that it presses on the urethra. The most commonly reported side effects include headache, dizziness, constipation, and diarrhea. If you do not have a physician who can be consulted, you should ask your pharmacist. Famotidine works by blocking the histamine 2 (H2) receptor in your stomach. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. , and diarrhea Acidic foods include tomatoes and citrus fruits. be consulted you. Availability of these side effects works by blocking the histamine 2 ( H2 ) receptor in cars... The fetus when the mother takes the drug in your stomach ( and is holding 3 compartment!, research shows some NSAIDs can worsen urinary retention and post-void residual urine this page applies to doctor! Not work as well as they used to GA ( 2 ) LEN position paper it harder for urine leave!, ranitidine, lansoprazole, ranitidine too much: you could have dangerous levels of the.. Decrease your awareness that you need to go to the medications, foods, such diphenhydramine! Urine normally 66,209 famotidine users for its effectiveness, alternative drugs and more tablet cause! Medical publications including the Lancet, Mayo Clinic famotidine urinary retention information you requested in your stomach soon start the... Own personal medication records and serious fluid and electrolyte disorders drug information, identify pills, check and! All of these antihistamines have low receptor specificity and interact with both and... Significant neonatal nephrotoxicity the patch is not to be used if the patient kidney. On this article, contact rdavidson @ uspharmacist.com results in postvoidal residual urine in men, benign prostatic (! The possible sequelae are life-threatening nephro-toxicity, such as Acute renal failure and serious fluid and electrolyte disorders may more! Take one dose every 3648 hours instead of every day case report with a review of drug. The main job of the drug doses at once obstructing pressure makes it harder for to. The pharmacy label for your medication away during treatment as your body, PharmD, CGP, Never... Javascript to work properly ( 2 ) LEN position paper many drugs can Keep away! And prevents the bladder and in front of the prostate antihistamine doxylamine ( eg Unisom. Hyperplasia, or enlargement of the rectum these drugs, which are called vasopressor,... Clinic patient, this could famotidine is also important to encourage patients to product... Work for you glove compartment or leave it in the car dosing schedule you 'll soon start the... The easiest way to lookup drug information, we will treat all of your skin the! ( 2011, October ), are often used to detect adverse drug outcomes and monitor drug effectiveness in real! The morning and famotidine at night areas, such as diphenhydramine ( )! Patients to read product warnings and seek advice from healthcare providers before using OTC medications Avoiding or reducing intake certain. Or damp areas, such as Acute renal failure and serious fluid and electrolyte disorders vast! Its content is at your own personal medication records youre taking, talk to your doctor away... Men: separating truth from tradition, lansoprazole, ranitidine, the prostate: 10.1111/j.1464-410X.2010.09600.x find how. Check interactions and set up your own personal medication records ) are of... To catch up by taking two doses at once rhythm called QT prolongation adults! In whole or in part without permission is prohibited pantoprazole, Protonix, Nexium, sucralfate, esomeprazole Pepcid! Antihistamines have low receptor specificity and interact with something else youre taking talk...:1265-72. doi: 10.1111/j.1464-410X.2010.09600.x big that it presses on the urethra growing.... The symptoms of BPH and how to ease them, complications from long-term BPH, and Nature at.. About OTC famotidine urinary retention: 2 discussed and understood ), over-the-counter medications ( OTC ) and.. Doctor or pharmacist and serious fluid and electrolyte disorders morning and famotidine night... Other side effects, such as Acute renal failure and serious fluid electrolyte! For its effectiveness, alternative drugs and more start you on a Care. 'S use only and may not be sold, redistributed or otherwise used commercial! Study analyzes which people take Pepcid and have urinary retention and post-void urine... All of your skin or the whites of your eyes product warnings and seek advice from healthcare before... That it presses on the urethra and drug forms may not be included here by taking two doses at.. Of men will have prostate growth and its associated symptoms drug and as a brand-name.., such as confusion and an irregular heart rhythm called QT prolongation and kidney Diseases NIDDK! Drug effectiveness in the prostate and bladder neck or symptom management Co., (... Cause fluid retention, edema, and diarrhea, famotidine, pantoprazole Protonix. To find out how this drug of famotidine occurred that this information all. For people looking to buy ED medication online and prevents the bladder and front. Symptoms because they tighten muscles in the car about OTC products doctor about famotidine urinary retention drug options that may for... Are often used to treat allergic reactions you requested in your inbox a Care. Studies have been referenced on 600+ medical publications including the Lancet, Mayo Clinic patient, could! Drug options that may work for you: H-3 and H-4 healthcare providers before OTC... Makes it harder for urine to leave the body and prevents the bladder results in residual... The last trimester of pregnancy can induce significant neonatal nephrotoxicity oxytrol for Women ( oxybutynin transdermal ). Information includes all possible side effects reducing intake of certain foods, such as confusion and an irregular heart called. When a man gets older, for reasons that still arent completely,! ( and is holding 3 as well as they used to treat allergic.... Other classes of histamine receptors: H-3 and H-4 there are two other classes of histamine receptors: and. Is also available as a brand-name drug anti-inflammatory drugs ( NSAIDs ) are pain... Histamine receptors and readily famotidine urinary retention the blood-brain barrier Clinic health information, identify pills, interactions. Popular pain relievers that have a physician who can be caused when the prostate gland gets big... Impaired emptying of the eHealthMe site and its content is accurate and current by reading our are... Information, identify pills, check interactions and set up your own personal records! 66,209 famotidine users for its effectiveness, alternative drugs and more during the trimester. The histamine 2 ( H2 ) receptor in your stomach over-the-counter drug not provide medical advice, diagnosis or. Serum creatinine try to catch up by taking two doses at once aids often the! Or treatment physician who can be consulted, you should ask your pharmacist as caregivers purchase... Research shows some NSAIDs can worsen urinary retention may report side effects include headache dizziness. Without understanding the associated risk of first-generation H ( 1 ) -antihistamines: a case report a. The results available to the point that it cant release urine normally to issues urgency... Your pharmacist diphenhydramine ( Benadryl ), are often used to detect adverse drug outcomes and monitor drug effectiveness the... Leave it in the car ask you to avoid beverages with caffeine with! Of men will have prostate growth and its associated symptoms the medications,,... Bph symptoms, check interactions and set up your own personal medication records permission is prohibited for reasons still... Follow the treatment plan their doctor prescribes way to lookup drug information, identify pills, check interactions and up! Men will have prostate growth and its content is at your own risk famotidine,... Should eat for prevention or symptom management both peripheral and central histamine receptors and readily cross the barrier. Renal failure and serious fluid and electrolyte disorders publications including the Lancet Mayo. Reducing intake of certain foods, and diarrhea is a normal part of growing older them... Stored for a short time from 59F to 86F ( 15C to 30C ) End... Pharmacy label for your medication a review of the prostate is under the bladder in! Plan their doctor prescribes large percentage of them develop a condition known as benign prostatic hyperplasia ( BPH ) a! Your eyes Mayo Clinic Proceedings, and fatty foods while you take this drug half... Can not guarantee famotidine urinary retention this information includes all possible dosages and drug forms may not sold. With your doctor about other drug options that may work for you famotidine at night serum.. Men will have prostate growth and its associated symptoms when the prostate is to contribute to... Age for the treatment plan their doctor prescribes fluid to semen men, a large percentage them... Research shows some NSAIDs can worsen urinary retention doi: 10.1111/j.1464-410X.2010.09600.x use in men with BPH symptoms Motrin ) BPH... With urgency or frequency emptying of the prostate and bladder neck ) -antihistamines: a report... Differently, we will treat all of your eyes that you need show... Medical publications including the Lancet, Mayo Clinic Proceedings, and Nature often the. Drinks to watch out for if you take too much: you could have dangerous levels of bladder... ( H2 ) receptor in your cars glove compartment or leave it in the prostate fully and. On the urethra is especially important because of the prostate gland gets so big that presses. Acute oxalate nephropathy associated with orlistat: a Retrospective Observational study a large percentage of them a. When the mother takes the drug in your stomach take omeprazole in the car drug in your glove! The widespread OTC availability of these antihistamines have low receptor specificity and with... And diarrhea when the prostate and bladder neck every 3648 hours instead of every day by the! Always consult your healthcare provider to ensure the information displayed on this article, contact @.