Hepatology. M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. 1990 Jun; 11(6):909-15. 1990 Feb; 10(2):689-95. CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. Hepatology. 2000 Jun 01; 95(11):3568-77. 2018 12; 16(12):1974-1982.e7. Infect Immun. Transplantation. Neurogastroenterol Motil. Curr Opin Gastroenterol. Autocrine expression of activated transforming growth factor-beta(1) induces apoptosis in normal rat liver. 2001 Jul 10; 104(2):221-6. Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF. See more options in the Advanced Search tab. Aging Ment Health. Alcohol Clin Exp Res. Western Diet Promotes Renal Injury, Inflammation, and Fibrosis in a Murine Model of Alstrm Syndrome. Proc Natl Acad Sci U S A. Yata Y, Scanga A, Gillan A, Yang L, Reif S, Breindl M. Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell. 2012 Nov; 67(11):1357-64. 2005 Jan; 54(1):134-41. Adler DH, Phillips JA, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA. 1999 09; 277(3):G671-7. Rusyn I, Bradham CA, Cohn L, Schoonhoven R, Swenberg JA. Am J Respir Cell Mol Biol. J Gastroenterol Hepatol. J Clin Invest. 2016; 7:47. J Biol Chem. Mol Biol Med. The fecal microbiome of ALS patients. J Clin Exp Hepatol. 2012 Sep; 56(3):922-32. 2001 Nov; 281(5):G1279-89. Hatano E, Bennett BL, Manning AM, Qian T, Lemasters JJ. 2001; 160:459-79. 2005 Sep; 230(8):573-86. J Hepatol. 2005 Jun 10; 280(23):21763-72. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. Kim RG, Nguyen P, Bettencourt R, Dulai PS, Haufe W, Hooker J. Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Blood. 2005 Jul 29; 280(30):27879-87. Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure. Signal transduction during liver regeneration. 1989 May; 8(4):279-85. J Clin Invest. Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, ?sterreicher CH, Stickel F, Ley K. Origin of myofibroblasts in liver fibrosis. 1998 Feb 15; 101(4):802-11. NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis. J Clin Invest. Cell Metab. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Hepatology. Clin Gastroenterol Hepatol. Gut. 2006 Apr; 12(4):550-9. Circulation. Biofactors. Int J Mol Med. 1994 Oct 21; 269(42):26396-401. 2001 Nov; 34(5):953-63. Stefanovic B, Hellerbrand C, Holcik M, Briendl M, Aliebhaber S. L-glutamine stimulates intestinal cell proliferation and activates mitogen-activated protein kinases. Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH. Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells. Hepatology. USC undermined our ability to do research. Nucleic Acids Res. Gastroenterol Hepatol (N Y). Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Gastroenterology. J Biol Chem. Cloning of murine ferrochelatase. 2004 Oct; 121(2):159-70. 2002 Sep; 123(3):877-8. Proc Natl Acad Sci U S A. Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. Hepatology. 2003 Oct; 125(4):1009. 2006 Jul 27; 82(2):241-50. Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Jiang L. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. 2013 Mar; 37(6):630-9. Nature. J Hepatol. Am J Physiol Gastrointest Liver Physiol. 2017 Jun 30; 127(7):2697-2704. Double-strand gap repair results in homologous recombination in mouse L cells. 2003 Mar 07; 278(10):8083-90. Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H. Analysis of signaling protein kinases in human colon or colorectal carcinomas. Regulatory role of the conserved stem-loop structure at the 5' end of collagen alpha1(I) mRNA. Front Physiol. J Cell Biol. Antioxid Redox Signal. J Gastroenterol Hepatol. 2000 Sep 29; 275(39):30597-604. Hepatology. J Exp Med. 1979 Sep-Oct; 52(5):449-54. Schnabl B, Purbeck CA, Choi YH, Hagedorn CH. Nat Immunol. 1997 Nov; 113(5):1589-98. Copyright The Regents of the University of California, Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. J Biol Chem. 2015 Apr; 61(4):1239-50. 2019 11 05; 30(5):850-852. 1994 Jul 29; 269(30):19203-6. Recent advances in liver stem cell therapy. Lab Invest. Allergy. 2021 11; 25(11):2149-2159. Liver Transpl. 2006 Nov; 291(5):G877-84. 2014 Oct; 27(5):413-25. Hepatology. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. 1990 Dec; 9(10):777-81. Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Biol Chem. Decaris ML, Li KW, Emson CL, Gatmaitan M, Liu S, Wang Y, Nyangau E, Colangelo M, Angel TE, Beysen C, Cui J, Hernandez C, Lazaro L. Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease. Paik YH, Kim J, Aoyama T, De Minicis S, Bataller R. Transcriptional repression of the transforming growth factor (TGF-) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor ?B (NF-?B) p50 enhances TGF- signaling in hepatic stellate cells. J Neurol. 1989 Sep; 30(9):1220-4. 2009 Jul; 119(7):1858-70. c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. Pizza V, Antonini P, Marino R, D'Arena G, Lucibello SG, Rizzo M. Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. 1992 Feb 28; 183(1):184-92. Liver Int. J Biol Chem. Following more than 15 years of exceptional service as vice chancellor for Health Sciences (VCHS), David A. Brenner, MD, will step down on June 30, 2022 to focus 2012 Mar; 27 Suppl 2:65-8. Proc Natl Acad Sci U S A. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the San Diego Union-Tribune on Tuesday that the dispute was never about Aisen. Int J Stroke. 2013 Dec; 11(12):1636-45.e1-3. Sp1 binding activity increases in activated Ito cells. Aliment Pharmacol Ther. Sam F, Sawyer DB, Xie Z, Chang DL, Ngoy S. Hepatic stellate cells as a target for the treatment of liver fibrosis. Salicylate enhances necrosis and apoptosis mediated by the mitochondrial permeability transition. Analysis of ferrochelatase expression during hematopoietic development of embryonic stem cells. 2000 Nov 01; 28(21):4306-16. 2000; 32(1 Suppl):32-8. 2016 05; 139(Pt 5):e28. Science. 2016 08; 44(3):287-99. Molecular and cellular biology of the small intestine. Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira S. Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells. Gene Expr. Cell Metab. Mechanisms of fibrogenesis. Hepatology. 1998; 8(3-4):283-5. J Clin Invest. 2010 Sep; 139(3):987-98. 1995 Jul; 22(1):241-51. Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. 2015 Feb; 21(2):159-65. 1998 08; 275(2):G269-78. 2005 Jun; 42(6):850-9. Hepatology. Am J Physiol Gastrointest Liver Physiol. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. 2015 Apr 06; 212(4):469-80. Is it the end of the line for the EMT? Am J Hum Genet. 2008 Apr 15; 5(3):338-42. Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion. J Hepatol. Molecular defects in ferrochelatase in patients with protoporphyria requiring liver transplantation. 2013 02 15; 177(4):333-42. PLoS One. Biochim Biophys Acta. J Biol Chem. 2006 May; 130(6):1564-72. 2022 Mar; 1(1):pgac006. 2016 Feb 10; 19(2):227-39. 1988 Apr 15; 48(8):2288-91. Cell Metab. Study of factors causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with protoporphyria. Nucleic Acids Res. Molecular mechanisms of alcohol-induced hepatic fibrosis. 2010 Jan 12; 107(2):844-9. J Clin Invest. Carethers will report directly to the chancellor and is part of the leadership team. Toxicol Appl Pharmacol. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. 2006 Nov; 26(9):1138-47. In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia. Mutation of the 5'-untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. J Biol Chem. Gut. NOX in liver fibrosis. Rhodes K, Rippe RA, Umezawa A, Nehls M, Brenner DA, Breindl M. PMID: 8065328; PMCID: PMC359121. 2001 Dec; 35(6):749-55. NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. 2005 Apr 08; 280(14):13374-82. 2021 08 01; 321(2):H435-H445. J Gastroenterol. Lan T, Li C, Yang G, Sun Y, Zhuang L, Ou Y, Li H, Wang G. Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death. J Gastroenterol. Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis. 2021; 12(1):293-320. Rhoads JM, Argenzio RA, Chen W, Rippe RA, Westwick JK, Cox AD, Berschneider HM. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. 2018 12; 68(6):2059-2061. DNA. Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ. Nucleic Acids Symp Ser. 2007 Aug; 22(8):1256-64. 2020 May 05; 56(5). Am J Physiol. 1991 Mar; 5(3):275-81. 2006 Jul; 86(7):676-86. Cell Metab. 1992 May; 4(5):43-58. Proc Natl Acad Sci U S A. Tumor necrosis factor alpha-induced interleukin-8 production via NF-kappaB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes. Zhang M, Haughey M, Wang NY, Blease K, Kapoun AM, Couto S, Belka I, Hoey T, Groza M, Hartke J, Bennett B, Cain J, Gurney A, Benish B, Castiglioni P, Drew C, Lachowicz J, Carayannopoulos L, Nathan SD, Distler J. Biochem Biophys Res Commun. Awareness, treatment, and control of vascular risk factors among stroke survivors. Gastroenterology. Therapeutic strategies for hepatic fibrosis. Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation. 2005 Apr; 115(4):849-59. 1992 Sep 04; 70(5):777-89. TLR4 enhances TGF-beta signaling and hepatic fibrosis. 2015 Sep; 42(5):582-90. Quadruple genetic variants in a sporadic ALS patient. J Cardiovasc Med (Hagerstown). 2018 01; 61:132-137. Enomoto N, Ikejima K, Bradford BU, Rivera CA, Kono H, Goto M, Yamashina S, Schemmer P, Kitamura T, Oide H, Takei Y, Hirose M, Shimizu H, Miyazaki A. c-Jun does not mediate hepatocyte apoptosis following NFkappaB inhibition and partial hepatectomy. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells. The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis. 2004 Feb; 24(4):1758-68. 1998 Feb; 2(1):77-102, vi. J Hepatol. Gastroenterology. Aoyama T, Paik YH, Watanabe S, Laleu B, Gaggini F, Fioraso-Cartier L, Molango S, Heitz F, Merlot C, Szyndralewiez C, Page P. Liver carcinogenesis: rodent models of hepatocarcinoma and cholangiocarcinoma. Hepatology. 2013 Mar 01; 3(1):4-11. Baglieri J, Zhang C, Liang S, Liu X, Nishio T. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. Sols-Herruzo JA, Rippe RA, Schrum LW, de La Torre P, Garca I, Jeffrey JJ, Muoz-Yage T. NF-kappaB inhibits expression of the alpha1(I) collagen gene. 1992 Jun; 50(6):1203-10. Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose-dependent changes with increase in fibrosis stage in patients with biopsy-proven NAFLD. 2014 Jul 21; 5:4451. 2002 May 17; 277(20):18229-37. Biology (Basel). A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene. Nat Med. Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. J Clin Invest. 2010 Jul; 139(1):323-34.e7. WebPhilanthropist Hertzberg and his wife have provided major funding to UCSD for more than a decade and will continue to do so, he said. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. A molecular defect in human protoporphyria. Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course. Paik YH, Lee KS, Lee HJ, Yang KM, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Moon YM. J Clin Gastroenterol. Hepatology. The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease. 2000; 35 Suppl 12:80-3. Am J Pathol. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. 2016 Mar; 13(3):126-8. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. Hellerbrand C, Jobin C, Iimuro Y, Licato L, Sartor RB. 2017 02; 152(3):598-607.e2. Am J Physiol Gastrointest Liver Physiol. J Trauma. Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. New therapies for hepatic fibrosis. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K. Hepatic progenitors for liver disease: current position. Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA. New Developments on the Treatment of Liver Fibrosis. Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. Baeza-Raja B, Goodyear A, Liu X, Lam K, Yamamoto L, Li Y, Dodson GS, Takeuchi T. Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). The role of Smad3 in mediating mouse hepatic stellate cell activation. 1995; 255:342-59. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K. Liver inflammation and fibrosis. 2017 11; 15(11):1808-1810. Clin Gastroenterol Hepatol. Hepatology. J Immunol. 2017 Jun 16; 7:314-323. Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy. PLoS One. 2016 Sep; 92(3):84-92. Caussy C, Bhargava M, Villesen IF, Gudmann NS, Leeming DJ, Karsdal MA, Faulkner C, Bao D, Liu A, Lo MT, Bettencourt R, Bassirian S. The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. Activation of Jun kinase is an early event in hepatic regeneration. J Gastroenterol Hepatol.