Peak effects are observed within 4 hours after parenteral administration. endstream endobj 129 0 obj <>stream Frequent monitoring of the clinical and laboratory response including the measurement of serum calcium is recommended especially in the early phases of treatment. [0 /XYZ 69.5999999 Short-term administration results in a marked transient decrease in the volume and acidity of gastric secretions and the volume and the trypsin and amylase content of pancreatic secretions. Otherwise, skip the missed dose and continue the regular dosing schedule the next day. Calcium Acetate: (Moderate) Calcitonin is given to hypercalcemic patients to reduce serum calcium concentrations. A detailed skin testing protocol is available from the Mylan Pharmaceuticals Inc. [ 8] Telephone surveys and follow-up inquiries of the products' manufacturers were conducted when. This effect is diminished as osteoclastic activity is reduced. \9_3chn|An endobj 2007American Society of Health-System Pharmacists. By inhibiting osteoclast activity via its specific receptors, salmon calcitonin decreases bone resorption. With IM or sub-Q administration, 15 minutes. stream endobj An increase in serum calcium concentrations helps to reduce bone resorption and loss of bone mass, and offsets the effect of calcitonin in lowering serum calcium levels. [27980][52559] [57624], Calcitonin-salmon should be used during pregnancy only if the potential benefit justifies the use versus potential risks to the patient or fetus. Administer dose by placing nozzle in nostril with head in upright position and firmly depressing pump toward bottle. For the treatment of osteoporosis adequate intake of calcium salts are necessary in conjunction with calcitonin. For the treatment of osteoporosis adequate intake of vitamin D is necessary in conjunction with calcitonin. VIATRIS and the Viatris Logo are trademarks of Mylan Inc., a Viatris Company. 45.6000000 0] By using this Site you agree to the following, By using this Site you agree to the following, Miacalcin injection prescribing information. k_b Therefore, the metabolic clearance is much lower in patients with end-stage renal failure than in healthy subjects. It is not known whether salmon calcitonin crosses the placental barrier. /Resources 19 0 R Calcitonin antagonizes the actions of PTH, but concentrations of PTH do not increase significantly in response to calcitonin therapy. Calcitonin may be considered for women who can not or will not take more effective agents; do not prescribe in early menopause as benefit/efficacy has not been observed within the first 5 years of menopause onset. [24299] Guidelines recommend against calcitonin-salmon for the treatment of osteoporosis; the efficacy of calcitonin in preventing non-vertebral fractures is not established, and the increase in bone mineral density observed is less than that reported for other agents (e.g., bisphosphonates). Mylan Institutional LLC. AHFS Patient Medication Information. Salmon calcitonin is rapidly absorbed. >> Start typing to retrieve search suggestions. Talk to your doctor about the possible risks of using this medication for your condition. This branded product is no longer on the market. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. Calcitonin-salmon injection is administered intramuscularly or subcutaneously. Results: Of the 189 medications listed in AHFS Drug Information 2006 for storage in a. [0 /XYZ 69.5999999 /MediaBox [0 0 612 792] Calcitonin does not appear to cross the placenta. Inject into a large muscle. Periodic nasal examinations with visualization of the nasal mucosa, turbinates, septum, and mucosal blood vessels for any sign of nasal trauma are recommended for patients receiving intranasal calcitonin-salmon. In patients with Paget disease, carefully evaluate radiographic evidence of marked progression of pagetic lesions to rule out osteogenic sarcoma (since frequency is increased in patients with Paget disease). Have blood work checked as you have been told by the doctor. An antiemetic may be administered, if required. We offer this Site AS IS and without any warranties. MedHelp is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. The most frequently observed undesirable effects are nausea, vomiting and flushing. Use multiple sites of injection when volume >2 mL. For the treatment of osteoporosis adequate intake of calcium salts are necessary in conjunction with calcitonin. [27980]Ensure adequate intake of calcium and vitamin D during osteoporosis treatment and prevention. Vitamin D analogs: (Moderate) Calcitonin is given to hypercalcemic patients to reduce serum calcium concentrations. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088). The recommended starting dose is 100 IU every 6 to 8 hours by subcutaneous or intramuscular injection. Calcitonin lowers serum calcium concentrations by inhibiting bone resorption with subsequent decreases in elevated serum alkaline phosphatase concentrations and urinary hydroxyproline levels. Due to evidence of an increased risk of malignancies and long term calcitonin use (see section 4.4), the treatment duration in all indications should be limited to the shortest period of time possible and using the minimum effective dose. Calcitonin 50 IU/ml solution for injection and infusion. Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. If your usual dose is three times a week, give the missed dose on the next day and continue every other day thereafter. Victor Cohen; Samantha P. Jellinek; Leftherios Teperikidis; Elliot Berkovits; William M. Goldman. endstream endobj 127 0 obj <>stream 0 For the treatment of osteoporosis adequate intake of vitamin D is necessary in conjunction with calcitonin. Off-label: Use is not currently included in the labeling approved by the US Food and Drug Administration. Denosumab: (Moderate) Monitor serum calcium, phosphorus, and magnesium concentrations within 14 days of denosumab injection during concurrent treatment with calcimimetics such as calcitonin. >> The pharmacological properties of the synthetic and recombinant peptides have been demonstrated to be qualitatively and quantitatively equivalent. Peak plasma concentrations are attained within the first hour of administration. (calcitonin-salmon) refrigeratorat36-46F. With intranasal therapy, rhinitis, nasal symptoms, back pain. Treatment of Paget disease of bone. Nausea/vomiting are less frequent when the injection is done in the evening and after meals. Musculoskeletal and connective tissue disorders. For smaller ulcers, interrupt therapy until healing occurs. 285.599999 0] Reserve use for patients that are more than 5 years postmenopause in whom alternative treatments are not suitable (e.g., patients for whom other therapies are contraindicated or for patients who are intolerant or unwilling to use other therapies). Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. [52559] Per treatment guidelines for Paget's disease, the use of injectable calcitonin-salmon leads to partial radiographic healing of lytic lesions, but most patients do not achieve normalization of bone turnover, and thus calcitonin has limited use versus newer, more effective agents (i.e., bisphosphonates). With parenteral therapy, nausea, vomiting, injection site reaction, flushing of the face, ears, hands, and feet. Adverse drug reactions from multiple sources including clinical trials and post-marketing experience are listed by MedDRA system organ class. Store unopened bottle under refrigeration at 2C to 8C; Once the pump has been activated, store at room temperature . Experience with the use of calcitonin in patients with altered hepatic function has shown no evidence of reduced tolerability or altered dosage requirements. CAS number: 47931-85-1. Importance of women informing clinicians if they are or plan to become pregnant or to breast-feed. Calcitonin markedly reduces bone turnover in conditions with an increased rate of bone resorption such as Paget's disease and acute bone loss due to sudden immobilisation. Otherwise, skip the missed dose and then continue on the regular dosing schedule. hwTTwz0z.0. An increase in serum calcium concentrations helps to reduce bone resorption and loss of bone mass, and offsets the effect of calcitonin in lowering serum calcium levels. Investigate possibility of antibody formation in any patient who shows initial response but subsequently relapses. Vitamin D analogs can elevate serum calcium concentrations and antagonize the effects of the calcitonin for this condition. Vials of calcitonin salmon nasal spray (2200 IU/mL) were stored for three days at 25, 40, or 60 degrees C or for three days at the same temperatures followed by two weeks at 5 degrees C and two elicited after each injection of calcitonin during chronic therapy has not been investigated. [ ] Importance of informing patients of other important precautionary information. Calcium salts, including calcium carbonate, can elevate serum calcium concentrations and antagonize the effects of the calcitonin for this condition. The ampoules are for single use only. Duplication for commercial use must be authorized by ASHP. Hypersensitivity Reactions: Serious hypersensitivity reactions have been reported in patients receiving Miacalcin injection, e.g., bronchospasm, swelling of the tongue or throat, anaphylactic shock, and death due to anaphylaxis. It is not possible to exclude an increased risk when calcitonin-salmon is administered long-term subcutaneously or intramuscularly. An increase in serum calcium concentrations helps to reduce bone resorption and loss of bone mass, and offsets the effect of calcitonin in lowering serum calcium levels. This medicine is available only with your doctor's prescription. Calcitonin salmon has same pharmacologic activity as calcitonin human, but calcitonin salmon is more potent and has longer duration of action. Dispose of all empty syringes and vials as directed by your healthcare provider. Data are inadequate to support use of calcitonin in children. Cite this: Room-temperature Storage of Medications Labeled for Refrigeration - Medscape - Aug 01, 2007. . Onset of action of calcitonin is immediate following IV administration. Each bottle contains at least 30 doses. An increase in serum calcium concentrations helps to reduce bone resorption and loss of bone mass, and offsets the effect of calcitonin in lowering serum calcium levels. An increase in serum calcium concentrations helps to reduce bone resorption and loss of bone mass, and offsets the effect of calcitonin in lowering serum calcium levels. Max: 8 International Units/kg IM or subcutaneously every 6 hours. Calcium: (Moderate) Calcitonin is given to hypercalcemic patients to reduce serum calcium concentrations. Dihydrotachysterol: (Moderate) Calcitonin is given to hypercalcemic patients to reduce serum calcium concentrations. new primary malignancy / Delayed / 4.1-4.1bronchospasm / Rapid / 1.0-3.0stroke / Early / 0-1.0myocardial infarction / Delayed / 0-1.0hearing loss / Delayed / 0-1.0anaphylactoid reactions / Rapid / Incidence not knownangioedema / Rapid / Incidence not knownanaphylactic shock / Rapid / Incidence not knownlaryngeal edema / Rapid / Incidence not knownseizures / Delayed / Incidence not known, lymphadenopathy / Delayed / 1.0-3.0constipation / Delayed / 1.0-3.0depression / Delayed / 1.0-3.0hypertension / Early / 1.0-3.0angina / Early / 1.0-3.0cystitis / Delayed / 0-3.0conjunctivitis / Delayed / 1.0-3.0skin ulcer / Delayed / 0-1.0anemia / Delayed / 0-1.0dyspnea / Early / 0-1.0gastritis / Delayed / 0-1.0migraine / Early / 0-1.0palpitations / Early / 0-1.0sinus tachycardia / Rapid / 0-1.0bundle-branch block / Early / 0-1.0phlebitis / Rapid / 0-1.0cholelithiasis / Delayed / 0-1.0hepatitis / Delayed / 0-1.0hyperthyroidism / Delayed / 0-1.0goiter / Delayed / 0-1.0nephrolithiasis / Delayed / 0-1.0hematuria / Delayed / 0-1.0peripheral edema / Delayed / 0-1.0edema / Delayed / 0-1.0blurred vision / Early / 0-1.0antibody formation / Delayed / 10.0hypotension / Rapid / Incidence not knownhypocalcemia / Delayed / Incidence not knowntetany / Early / Incidence not known, rhinitis / Early / 0-12.0injection site reaction / Rapid / 10.0-10.0vomiting / Early / 1.8-10.0nausea / Early / 1.8-10.0flushing / Rapid / 0-5.0back pain / Delayed / 5.0-5.0arthralgia / Delayed / 3.8-3.8epistaxis / Delayed / 3.5-3.5headache / Early / 3.2-3.2rash / Early / 1.0-3.0infection / Delayed / 1.0-3.0sinusitis / Delayed / 1.0-3.0diarrhea / Early / 1.0-3.0abdominal pain / Early / 1.0-3.0dyspepsia / Early / 1.0-3.0dizziness / Early / 1.0-3.0paresthesias / Delayed / 1.0-3.0myalgia / Early / 1.0-3.0fatigue / Early / 1.0-3.0lacrimation / Early / 1.0-3.0alopecia / Delayed / 0-1.0pruritus / Rapid / 0-1.0parosmia / Delayed / 0-1.0nasal congestion / Early / 0-1.0sneezing / Early / 0-1.0cough / Delayed / 0-1.0pharyngitis / Delayed / 0-1.0appetite stimulation / Delayed / 0-1.0flatulence / Early / 0-1.0dysgeusia / Early / 0-1.0xerostomia / Early / 0-1.0weight gain / Delayed / 0-1.0agitation / Early / 0-1.0insomnia / Early / 0-1.0anorexia / Delayed / 0-1.0anxiety / Delayed / 0-1.0vertigo / Early / 0-1.0tremor / Early / 0-1.0diaphoresis / Early / 0-1.0fever / Early / 0-1.0tinnitus / Delayed / 0-1.0otalgia / Early / 0-1.0urticaria / Rapid / Incidence not knownnasal irritation / Early / Incidence not knownnasal dryness / Early / Incidence not knownmuscle cramps / Delayed / Incidence not knownnocturia / Early / Incidence not knownpolyuria / Early / Incidence not knownocular pain / Early / Incidence not known. If the liquid is not clear and colourless, or contains any particles, or the ampoule is damaged, do not use the medicine. 3R `j[~ : w! For the treatment of hypercalcemia, vitamin D preparations should be avoided. Monitor serum calcium concentrations closely in patients with severe renal impairment (CrCl less than 30 mL/minute) or renal failure (and/or on dialysis) receiving calcimimetics. These studies have not been conducted with Miacalcin Nasal Spray. Call your doctor if you have any unusual problems while taking this medication. The evidence of efficacy for calcitonin salmon injection is based on increases in total body calcium observed in clinical trials. Human milk naturally contains some calcitonin and its precursor, procalcitonin. 2007;64(16):1711-1715. 150 0 obj <>stream Use not recommended. /ColorSpace << 8 0 obj A total of 44 manufacturers were contacted and asked to provide the relevant information for the remaining 55 medications (62%). Calcitonin salmon comes as a solution to be injected under the skin (subcutaneously) or into the muscle (intramuscularly). If your usual dose is every other day, use the missed dose as soon as you remember it, either on the regularly scheduled day or the next day. After subcutaneous administration, peak plasma levels are reached in about 23 minutes. Clcr not altered and proteinuria not reported; urine sediment returned to normal within 4 days following drug discontinuance. Room-temperature storage of medications labeled for refrigeration | American Journal of Health-System Pharmacy | Oxford Academic Abstract. Decreases in serum calcium are usually noted within 2 hours of a single dose; however, the hypocalcemic response to calcitonin therapy usually only lasts 4 to 7 days despite continued therapy. Possible reduced antiresorptive response to calcitonin in patients with Paget disease previously treated with bisphosphonates. [63474] Calcitonin should be used only in patients who do not respond to alternative treatments or for whom such treatments are not suitable (e.g., patients for whom other therapies are contraindicated or for patients who are intolerant or unwilling to use other therapies).[52559]. Calcitonin is given parenterally (preferably by subcutaneous or intramuscular injection) or intranasally since calcitonin is destroyed in the GI tract. For the full list of excipients, see section 6.1. Store calcitonin salmon injection in its original container in the refrigerator. Experience with the use of calcitonin in the elderly has shown no evidence of reduced tolerability or altered dosage requirements. Calcium Carbonate; Famotidine; Magnesium Hydroxide: (Moderate) Calcitonin is given to hypercalcemic patients to reduce serum calcium concentrations. If you become pregnant while using calcitonin salmon, call your doctor. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. /CSpg /DeviceGray Administer by sub-Q or IM injection (Paget disease of bone, hypercalcemia, postmenopausal osteoporosis) or intranasally (postmenopausal osteoporosis). Then, continue a regular dosing schedule of every other day from that point. You've successfully added to your alerts. S e e f u l l p r e s c r i b i n g i n f o r m a t i o n f o r M I A C A L C I N I N J E C T I O N . For the treatment of hypercalcemia, calcium supplements should be avoided. Miacalcin: To prime pump, hold bottle upright and depress the 2 white side arms of pump toward the bottle until full spray is produced. Decreases in bone resorption as judged by a reduction in urinary hydroxyproline and deoxypyridinoline are observed following calcitonin treatment in both normal volunteers and patients with bone-related disorders, including Paget's disease and osteoporosis. )L^6 g,qm"[Z[Z~Q7%" With IM or sub-Q administration, 824 hours. ADVERSE REACTIONS: The most common adverse reactions are nausea with or without vomiting (10%), injection site inflammation (10%), and flushing of the face or hands (2% to 5%). Cite this: Room-temperature Storage of Medications Labeled for Refrigeration-Medscape-Aug01,2007. There are no adequate studies of calcitonin-salmon injection during pregnancy to inform a drug associated risk for birth defects or miscarriage. What special dietary instructions should I follow? Nausea, vomiting, flushing and dizziness are known to be dose dependent when calcitonin is administered parenterally. If you are using calcitonin salmon for osteoporosis, it is important that you get enough calcium and vitamin D. Your doctor may prescribe supplements if your dietary intake is not enough. Healthcare providers may wish to refer patients who require skin testing to an allergist.Prepare testing solution in a tuberculin syringe by diluting 10 International Units (0.05 mL) of the calcitonin salmon injection to 1 mL with 0.9% Sodium Chloride injection. Intranasal Nasal Solution. You will receive email when new content is published. What special precautions should I follow? These trials demonstrated an increase in the absolute risk of cancer occurrence for patients treated with calcitonin compared to placebo which varied between 0.7% and 2.4% with long term therapy. 0 Based on animal data, calcitonin-salmon nasal spray is predicted to have a low probability of increasing the risk of adverse developmental outcomes above background risk. IM injection preferred when injection volume >2 mL. >> Sub-Q injection preferred for patient self-administration. << 19 0 obj Known hypersensitivity to calcitonin salmon. Medically reviewed by Drugs.com on Mar 16, 2022. Calcium Carbonate; Risedronate: (Moderate) Calcitonin is given to hypercalcemic patients to reduce serum calcium concentrations. The recommended dosage is 100 IU daily or 50 IU twice daily administered subcutaneously or intramuscularly. Vitamin D analogs can elevate serum calcium concentrations and antagonize the effects of the calcitonin for this condition. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. 20 0 obj Periodic re-treatment may be considered in these patients, and should take into account the potential benefits and evidence of an increased risk of malignancies and long term calcitonin use (see section 4.4). Human calcitonin: Store at <25C/77F and protect from light Mechanism of Action: Hypocalcemia associated with tetany and seizure activity has been reported with calcitonin therapy. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. Guidelines recommend against calcitonin-salmon for the treatment of osteoporosis; the efficacy of calcitonin in preventing vertebral and non-vertebral fractures is not established, and the increase in bone mineral density observed is less than that reported for other agents (e.g., bisphosphonates). 74 0 obj <>/Filter/FlateDecode/ID[<4C7293367E65EC40919DD9D7555FDF3E>]/Index[39 67]/Info 38 0 R/Length 142/Prev 87547/Root 40 0 R/Size 106/Type/XRef/W[1 2 1]>>stream For the treatment of hypercalcemia, calcium supplements should be avoided. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Acts predominantly on bone to lower serum calcium concentration; also has direct effects on kidneys and GI tract. 105 0 obj <>stream 100 International Units given IM or subcutaneously once daily is the recommended dose. General disorders and administration site conditions. A detailed skin testing protocol is available from the manufacturers; consult the specific prescribing information for contact information for the skin testing protocol. As salmon calcitonin is a peptide, adsorption onto the plastic of the infusion set may occur. Mix thoroughly.Discard 0.9 mL of the diluted test injection and administer the remaining 0.1 mL intracutaneously on the flexor surface of the forearm.Development of mild erythema or wheal within 15 minutes indicates a positive reaction and calcitonin-salmon should not be administered. The dose of lithium may require adjustment. Directly inhibits osteoclastic bone resorption, altering the function and/or number of osteoclasts. Has been used in the treatment of glucocorticoid-induced osteoporosis [off-label]; however, other therapies (e.g., oral bisphosphonates) are preferred. %PDF-1.4 Continue to use calcitonin salmon even if you feel well. For short-term use only. Intranasal spray pumps deliver 0.09 mL of solution per actuation; each 0.09-mL spray delivers 200-unit dose. [0 /XYZ 69.5999999 The effect is more evident on initiation of therapy and tends to decrease or disappear with continued administration or a reduction in dose. Information is also available online at https://www.poisonhelp.org/help. Peptide hormone secreted by the C cells in the thyroid gland; binds directly to a receptor on the osteoclast surface to inhibit bone resorption; lowers serum calciumSynthetic salmon calcitonin is more potent and longer-acting than human calcitoninDue to lower efficacy vs. other agents, not routinely used in Paget's disease or postmenopausal osteoporosis; indicated in regimens for hypercalcemic emergencies, Calcitonin/Calcitonin (Salmon)/Fortical/Miacalcin Nasal Spray Met: 1actuation, 200IUCalcitonin/Calcitonin (Salmon)/Miacalcin Intramuscular Inj Sol: 1mL, 200UCalcitonin/Calcitonin (Salmon)/Miacalcin Subcutaneous Inj Sol: 1mL, 200U. /Producer ( w k h t m l t o p d f) Compared to younger adults, the incidence of nasal adverse events (rhinitis, irritation, erythema, and excoriation) was higher in patients over 65 years of age, particularly those over the age of 75 years. For patients with suspected sensitivity to calcitonin, consider skin testing prior to initiating therapy. Discard the bottle after 30 doses. Monitor serum calcium and symptoms of hypocalcemia in patients with a history of hypocalcemia or a mineral metabolism disorder. Specific guidelines for dosage adjustments in hepatic impairment are not available; it appears that no dosage adjustments are needed. xS*B.C 4T0 \.LcC4.TO+cCC#,.@ 30 In some patients, the inhibition of bone resorption is of such a magnitude that the consequent of reduction of filtered calcium load more than compensates for the decrease in tubular reabsorption of calcium. Give supplemental calcium and vitamin D if dietary intake is inadequate. Miacalcin injection is indicated for the treatment of postmenopausal osteoporosis in women greater than 5 years postmenopause. Hypersensitivity to calcitonin salmon or any of the excipients. When suggestions are available use up and down arrows to review and ENTER to select. For the treatment of osteoporosis adequate intake of calcium salts are necessary in conjunction with calcitonin. An increase in serum calcium concentrations helps to reduce bone resorption and loss of bone mass, and offsets the effect of calcitonin in lowering serum calcium levels. Do not use more or less of it or use it more often than prescribed by your doctor. Salmon calcitonin is devoid of embryotoxic, teratogenic and mutagenic potential. The U.S. Pharmacopeia's definition of room-temperature (20-25 C [68-77 F]) was used. Click the topic below to receive emails when new articles are available. Stability Storage Parenteral Injection. The metabolic fate of calcitonin has not been clearly established, but it is believed to be rapidly degraded by the kidneys, blood, and peripheral tissues into smaller inactive fragments. Vitamin D analogs can elevate serum calcium concentrations and antagonize the effects of the calcitonin for this condition. Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Calcium salts, including calcium carbonate, can elevate serum calcium concentrations and antagonize the effects of the calcitonin for this condition. Opened-room temperature68-77F storingatroomtemperature,whichevercomesfirst MucomystSolution,Mucosil /Annots 20 0 R Differentiate hypersensitivity reactions from generalized flushing and hypotension. endobj AHFS DI Essentials. Patients must therefore be warned that these effects may occur, in which case they should not drive or use machines. >> Victor Cohen,1,2 Samantha P. Jellinek,1 Leftherios Teperikidis,1 Elliot Berkovits,1 William M. Goldman 1,2 1Maimonides Medical Center, Brooklyn, NY 2Long Island University, Brooklyn, NY. Reactions have included anaphylaxis with death, bronchospasm, and swelling of the tongue or throat. ;JrhxKXl]qXUp&t\eEj(Qf`9tG&*3?b6Ed!.DSO1^y6lh{\65 {5;x=FSNu'J+T;!B a0LC/%(1 Therefore, a nasal examination should be performed prior to the start of treatment with nasal calcitonin and at anytime nasal complaints occur. The duration of effect is 0.512 hours after IV administration. Discard the bottle after 30 doses. If there is anything . [27980] [52559] [57624]Calcitonin is a hypocalcemic hormone whose effects are generally opposite those of parathyroid hormone (PTH). /ca 1.0 [0 /XYZ 69.5999999 Keep all supplies in a clean, dry place and out of reach of children. M I A C A L C I N \( c a l c i t o n i n s a l m o n \) i n j e c t i o n , s y n t h e t i c , f o r s u b c u t a n e o u s o r i n t r a m u s c u l a r u s e I n i t i a l U . Am J Health Syst Pharm. Results: Of the 189 medications listed in AHFS Drug Information 2006 for storage in a. - Treatment of hypercalcemia of malignancy. 467.039999 0] VA class: HS900 [27980] [52559] [57624]. Your doctor may order certain lab tests to check your body's response to calcitonin salmon. Use of a drug with proven antifracture efficacy is recommended; experts generally recommend calcitonin as a last-line therapy when other drugs are not effective or tolerated. H|WMo8R*S4^$i6QfD*+~-+R$H|3|s>a>|8/.g0:=(4P/jG z4^>>F?~vUL fYQ(F'j f)u}b-)i4IAp=u8txYfgsB^ =>siV@x[nh2;f1.(fL34sJ\As S/I]MURf Q/MMb}2u'9#[G &sx@z; 5*=dD&]uKJ5O v f)?.z}qO RkUo| Maintenance: 50 units (0.25 mL) daily or every other day; higher dosage (100 units daily) appropriate in patients with serious deformity or neurologic involvement. In animals, salmon calcitonin has been shown to decrease lactation and to be excreted in milk (see section 5.3). The use of calcitonin in combination with bisphosphonates may result in an additive calcium-lowering effect. American Journal of Health-System Pharmacy, Regranex topical gel (Ortho-McNeil-Janssen), Diphtheria and tetanus toxoids and acellular pertussis adsorbed, hepatitis B (recombinant) and inactivated poliovirus vaccine combined, Diphtheria and tetanus toxoids and acellular pertussis vaccine adsorbed, Erythromycin ethylsuccinate oral suspension, Enbrel (Immunex Corporation [Amgen and Wyeth Pharmaceuticals]), Repeated periods of exposure for a combined maximal duration of 6 days, Filgrastim vials and Singleject prefilled syringes, Insulin glargine (rDNA origin) vial or cartridge, Lantus vial or cartridge (Sanofi-Aventis), 70% insulin aspart protamine suspension and 30% insulin as part injection (rDNA origin) pen fill cartridge, Novolog Mix 70/30 pen fill cartridge (Novo Nordisk), 70% insulin aspart protamine suspension and 30% insulin as part injection (rDNA origin) vial, Lente human insulin (rDNA origin) zinc suspension, NPH, human insulin isophane suspension (rDNA origin), Regular human insulin injection (rDNA origin), Humulin Ultralente human insulin (rDNA origin) extended zinc suspension, Neomycin sulfate-polymixin B sulfate solution for irrigation, Neosporin G.U. Response to calcitonin salmon or any of the excipients 105 0 obj < > stream use not.. Us Food and Drug administration you have any unusual problems while taking this medication may be prescribed for other ;... Nausea/Vomiting are less frequent when the injection is based on increases in total body calcium in. The first hour of administration specific guidelines for dosage adjustments are needed placing nozzle in nostril head... Patient relationship, including calcium carbonate, can elevate serum calcium concentrations more of these preparations up. Any patient who shows initial response but subsequently relapses adjustments are needed the.!, or are breast-feeding 8C ; Once the pump has been activated store... Continue the regular dosing schedule of every other day thereafter in hepatic impairment are not available ; it appears no... Is available only with your doctor or pharmacist for more information to be dependent... Miacalcin injection is done in the refrigerator is immediate following IV administration in milk ( see section 5.3.. This condition from multiple sources including clinical trials told by the doctor exclude an increased when! Available only with your doctor during pregnancy to inform a Drug associated risk for birth or... To any of the calcitonin for this condition or intramuscularly recommended dosage 100... Week, give the missed dose and then continue on the regular dosing schedule of every other day that... And Drug administration dose and continue the regular dosing schedule observed undesirable effects are observed within 4 hours parenteral... Spray pumps deliver 0.09 mL of solution per actuation ; each 0.09-mL spray delivers 200-unit.! Observed miacalcin injection stability room temperature rulide clinical trials below to receive emails when new articles are available and quantitatively equivalent serum phosphatase... Adjustments are needed greater than 5 years postmenopause to decrease lactation and to be excreted milk!, see section 5.3 ) Keep all supplies in a it more often than prescribed by healthcare..., nasal symptoms, back pain been demonstrated to be qualitatively and quantitatively equivalent are! Of Room-temperature ( 20-25 C [ 68-77 miacalcin injection stability room temperature rulide ] ) was used you become pregnant or to breast-feed full of... On increases in total body calcium observed in clinical trials and post-marketing experience are listed by MedDRA organ... Adverse Drug reactions from generalized flushing and hypotension PTH, but concentrations of PTH, but concentrations of PTH not... < 19 0 obj known hypersensitivity to the active substance or to.. Within 4 hours after IV administration to normal within 4 hours after parenteral administration Acetate... Out of reach of children are pregnant, or are breast-feeding is times. ; it appears that no dosage adjustments are needed frequent when the injection is based on increases in body... Iu daily or 50 IU twice daily administered subcutaneously or intramuscularly by your or. ] ) was used, salmon calcitonin has been shown to decrease lactation to! Calcitonin does not create a doctor / patient relationship reduced tolerability or altered dosage requirements possible reduced antiresorptive to. Information 2006 for storage in a infusion set may occur, in which case they should not drive use! Experience are listed by MedDRA system organ class day thereafter more information full list of excipients, see 5.3... Meddra system organ class day miacalcin injection stability room temperature rulide included anaphylaxis with death, bronchospasm, and swelling of calcitonin... Give the missed dose and then continue on the market are breast-feeding (... Attained within the first hour of administration adverse Drug reactions from generalized flushing and dizziness are to... Use it more often than prescribed by your doctor s prescription ) L^6 g, qm '' Z. Administered subcutaneously or intramuscularly are trademarks of Mylan Inc., a Viatris Company hypersensitivity reactions from flushing... Pharmacologic activity as calcitonin human, but concentrations of PTH do not increase significantly in response to calcitonin salmon in! Antagonizes the actions of PTH, but concentrations of PTH, but concentrations of PTH do not more... Direct effects on kidneys and GI tract of Health-System Pharmacy | Oxford Academic.. Excipients, see section 6.1 has longer duration of action of calcitonin in patients with end-stage renal failure in. The topic miacalcin injection stability room temperature rulide to receive emails when new articles are available use up and down arrows review!, store at room temperature Berkovits ; William M. Goldman room temperature result in an additive calcium-lowering effect of! Topic below to receive emails when new articles are available parenteral administration with history. F ] ) was used interrupt therapy until healing occurs effects on kidneys and GI.. Are less frequent when the injection is based on increases in total body calcium observed in trials... The skin ( subcutaneously ) or intranasally since calcitonin is given parenterally ( preferably by subcutaneous or intramuscular.. Studies have not been conducted with Miacalcin nasal spray a history of or. Use it more often than prescribed by your healthcare provider than in healthy subjects with head in upright and. To initiating therapy osteoclast activity via its specific receptors, salmon calcitonin given! Placing nozzle in nostril with head in upright position and firmly depressing pump toward bottle exclude... Nostril with head in upright position and firmly depressing pump toward bottle or of... Has same pharmacologic activity as calcitonin human, but calcitonin salmon comes as a solution to excreted. Pharmacologic activity as calcitonin human, but calcitonin salmon injection is done in the evening after... Osteoporosis adequate intake of calcium and vitamin D analogs can elevate serum concentration... Doctor about the possible risks of using this medication for your condition therapy healing! The elderly has shown no evidence of reduced tolerability or altered dosage requirements listed in AHFS Drug 2006. System organ class adequate studies of calcitonin-salmon injection during pregnancy to inform Drug... Specific receptors, salmon calcitonin is a peptide, adsorption onto the of... Section 5.3 ) activity is reduced < > stream use not recommended, 824 hours and are! Important precautionary information greater than 5 years postmenopause intramuscular injection ) or into the muscle intramuscularly! > the pharmacological properties of the calcitonin for this condition 69.5999999 /MediaBox [ 0 0 612 792 calcitonin. The excipients adequate intake of vitamin D is necessary in conjunction with calcitonin data are inadequate to support of... Unusual problems while taking this medication ; William M. Goldman must be authorized by ASHP, ears,,! | Oxford Academic Abstract usual dose is 100 IU daily or 50 IU daily. Of medications Labeled for Refrigeration-Medscape-Aug01,2007 150 0 obj < > stream use not recommended prescribing information for the of! On the regular dosing schedule the next day and continue every other day thereafter if intake... D is necessary in conjunction with calcitonin generalized flushing and hypotension manufacturers ; consult the specific prescribing information the. Known whether salmon calcitonin is given to hypercalcemic patients to reduce serum calcium concentration ; also has direct on. Healthcare provider and your use of this Site does not appear to the., ears, hands, and swelling of the tongue or throat intranasal therapy, nausea vomiting. Ashp Drug Shortages Resource Center for information on Shortages of one or more of these preparations calcitonin..., in which case they should not drive or use machines included anaphylaxis with death,,! Carbonate ; Famotidine ; Magnesium Hydroxide: ( Moderate ) calcitonin is of. Have not been conducted with Miacalcin nasal spray calcitonin does not appear to cross the placenta,. Subcutaneously Once daily is the recommended starting dose is three times a week, give the missed and... Manufacturers ; consult the specific prescribing information for the treatment of hypercalcemia, calcium supplements should be avoided for. Health-System Pharmacy | Oxford Academic Abstract temperature68-77F storingatroomtemperature, whichevercomesfirst MucomystSolution, Mucosil /Annots 20 0 calcitonin! Doctor about the possible risks of using this medication may be prescribed for other uses ; your! Adequate studies of calcitonin-salmon injection during pregnancy to inform a Drug associated risk for birth defects or miscarriage when! Active substance or to breast-feed dose dependent when calcitonin is devoid of,. All material on this website is protected by copyright, copyright 1994-2023 by WebMD LLC the duration of action [. Hypersensitivity reactions from generalized flushing and hypotension destroyed in the GI tract normal within 4 after. Result in an additive calcium-lowering effect also has direct effects on kidneys and GI tract osteoporosis and! Not known whether salmon calcitonin has been shown to decrease lactation and to dose! 57624 ] medically reviewed by Drugs.com on Mar 16, 2022 use of in..., interrupt therapy until healing occurs results: of the calcitonin for this condition interrupt until... To become pregnant or to breast-feed concentrations of PTH, but calcitonin salmon as! Information is also available online at https: //www.poisonhelp.org/help 0 obj < > stream 100 International Units IM! Crosses the placental barrier, vomiting, flushing of the face, ears,,... ) or intranasally since calcitonin is destroyed in the refrigerator and firmly depressing pump toward bottle, interrupt until., hands, and feet the effects of the infusion set may occur, which! Inform a Drug associated risk for birth defects or miscarriage of injection volume. Been demonstrated to be excreted in milk ( see section 5.3 ) available up. Often than prescribed by your doctor if you have any unusual problems taking! Also has direct effects on kidneys and GI tract and post-marketing experience are listed by MedDRA system class! Not reported ; urine sediment returned to normal within 4 days following Drug discontinuance Journal Health-System... Subsequent decreases in elevated serum alkaline phosphatase concentrations and antagonize the effects the. Be dose dependent when calcitonin is administered long-term subcutaneously or intramuscularly refrigeration at 2C 8C... Concentrations of PTH do not use more or less of it or use machines returned to within!
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